The gene vdr encodes a transcriptional regulator that manages the expression of vitamin D-dependent family genes. The protein contains a zinc-finger DNA-binding domain, a transcriptional activation domain and a ligand binding web page. The necessary protein is a member of the steroid and thyroid junk receptor superfamily.
The T > C allele of the FokI polymorphism in the translation begin site of vdr results in a shortened protein that lacks a practical activation domain name. It is characterized by decreased products to transcription factor IIB and reduced transactivation activity. The occurrence of the variant allele may differ among ethnic groups. It is often implicated in variations in calcium consumption, bone mineral density (BMD), and anthropometric measurements.
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